The Cure’ book summary

‘The Cure’ is centered around a father’s refusal to give up hope in his children. John and Aileen Crowley are hit with the worst news of their lives after two of their three children are diagnosed with Pompe disease, a rare, untreatable, and fatal genetic disease which attacks the muscles. The condition gradually degenerates muscles until the victim cannot sit or breathe. The condition also enlarges the heart to a dangerous degree, which eventually causes death. With sheer determination to save his children, John Crawley starts up a biotech company to develop a cure for the disease, to protect his children. The disease strikes about 10,000 people annually, and since there is no known cure, pharmaceutical companies lack the financial incentive to develop a treatment. However, John refuses to accept the situation and sets his mind to push through with his plans.

When John discovers that no drug company is willing to commit to finding the cure, he immerses himself in the quest to save his children, using everything he had. As his finances shrink, John approaches venture companies to fund his research. Despite the rejection of these venture capitalists, John refuses to give up. At last, a venture capitalist called Catalyst invests 3 million in it. After John’s company proves to have great potential, Genzyme, a Cambridge based capitalist firm, acquires John’s company, pays $ 137.5 million, and makes John a senior vice president at Genzyme. In his position, John continues to push hard for Pompe’s research. He also ensures that his two children are included in clinical trials of developed drugs. Executives within Genzyme were under the impression that John has an apparent conflict of interest since he bends corporate strategy based on his desire to save his children, this leads to his children being rejected more than once, for the clinical study. However, the children finally receive the treatment that their father helped to create and live beyond their fifth birthday (Anand, 2006).


Genetic and clinical aspects of Pompe Disease                 

Pompe Disease is a rare genetic disorder inherited as a recessive trait. It is caused by a mutation in a gene that makes an enzyme GAA (acid alpha-glucosidase) (Kohler et al., 2018). This mutation restricts the body’s ability to produce enough protein to break down glycogen for energy. Sugar builds up in the body, causing fatal damage to the organs (liver, heart, and lungs) and muscles. The disease also causes trouble breathing and weakness due to degenerated muscles.Pompe disorder is estimated to affect one child in every 40,000 births, according to Byrne et al. (2019).

Impacts of Pompe disorder on the family structure

Generally, the Pompe disease puts a significant strain on a family’s wellbeing in several aspects. The affected member spends a substantial amount of time in the hospital, which requires support from other family members. Thus, couples spend most of their time providing care, whether at home or in the hospital, and less time on their marriage. Since all the attention is focused on the patient, parents may spend less time with other children, which may affect them psychologically. The Pompe disease also puts a strain on the family’s finances, since most of the money is directed towards providing health care for the affected member.

Orphan drug

An orphan drug is a medicinal product intended for the prevention, diagnosis, and treatment of rare, life-threatening disorders. This drug is termed ‘orphan’ because, under normal market conditions, pharmaceutical companies have little interest or commitment in developing and marketing medicines intended for the treatment of a minimal number of patients (Sharma et al., 2010). Thus, pharmaceutical companies avoid developing orphan drugs, as expected sales of the medicine cannot recover the high cost of establishing the product in the market. Consequently, the potential market for an orphan drug is tiny, and drug companies would incur an enormous financial loss. In the book, John had to start his own drug company, since no pharmaceutical firm was willing to develop an orphan drug for Pompe Disease.

Moreover, most venture capitalists turned John away, since they saw no profitability in investing in his company


Roles of pharmaceutical companies and FDA in drug development

The primary function of pharmaceutical companies is to discover and develop drugs that are marketed for use as a medication to prevent, cure, or alleviate the symptoms of a disease. Pharmaceutical corporations, therefore, create value that improves the wellbeing of patients. On the other hand, the FDA (Food and Drug Association)is a regulating organization that protects public health. The FDA accomplishes its function by ensuring that pharmaceutical companies prove the efficacy and safety of a developed drug (Darrow et al., 2020). The FDA also makes sure that drug companies manufacture and market medicinal products appropriately. Thus, the FDA is a critical consumer watchdog for pharmaceutical corporations, which guarantees consumers that developed drugs are effective and safe for their intended use.

Phases of drug development

Several mandatory processes grope the pharmaceutical industry before the sale of a drug can commence on the market. The FDA outlines five comprehensive stages of drug development (Dugger et al., 2020). The first is discovery and development. Here, drug companies conduct substantial research and scientific studies on a particular disease while spending millions of dollars. They obtain funds from grants, own revenues, and even governments. The second phase is preclinical research, which is a preliminary stage that involves testing drugs on animals. Safety testing is also carried out to determine the effects of the drug. The third stage is clinical research, which is one of the most critical phases of drug development. After the drug is cleared from preclinical trials, it goes on to be tested on humans in the clinical trial. The FDA regulates specific standards for clinical trials such as scientific testing, selection criteria of humans being tested as well as the environment in which the test is being done. The fourth phase is the FDA review, where pharmaceuticals submit fully documented findings and conclusions of clinical research to the FDA for review. If the FDA accepts the submission, a response is provided within 6 to 10 months. The last phase is the PDA post-market safety monitoring. Here, the FDA closely monitors the advertisement of the drug for accuracy. The FDA also monitors problems and complaints associated with the drug. The FDA, therefore, has the power to offer warnings and restrict drug sales. Overall, the FDA conducts routine manufacturing inspections to ensure safety standards are upheld (Darrow et al., 2020).

Book evaluation

Once a reader gets hold of the boo, it is hard to put it down. However, one can get frustrated and even disappointed in some of the impulsive and unwise approaches that John takes in the quest to save his children. Nonetheless, his determination to find a cure and the unwillingness to accept the fate brought by the genetic disease is genuinely admirable. The book points out the fierce competition and tension between pharmaceutical companies, physicians, research scientists, healthcare providers, and parents. John refuses to sit back and wait for the system to work in favor of his children. He disregards the wait on research processes and approval of the FDA. The reader also gets to comprehend that only someone with John’s connections and position could have made the moves to raise finances for research possible, which is unlikely for most people.





Anand, G. (2006). The Cure: How a Father Raised $100 Million–and Bucked the Medical Establishment–in a Quest to Save His Children. Harper Collins.

Kohler, L., Puertollano, R., & Raben, N. (2018). Pompe disease: from basic science to therapy. Neurotherapeutics, 15(4), 928-942.

Byrne, B. J., Fuller, D. D., Smith, B. K., Clement, N., Coleman, K., Cleaver, B., … & Corti, M. (2019). Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy. Annals of Translational Medicine, 7(13).

Sharma, A., Jacob, A., Tandon, M., & Kumar, D. (2010). Orphan drug: Development trends and strategies. Journal of Pharmacy and Bioallied Sciences, 2(4), 290.

Darrow, J. J., Avorn, J., & Kesselheim, A. S. (2020). FDA Approval and Regulation of Pharmaceuticals, 1983-2018. JAMA, 323(2), 164-176.

Dugger, S. A., Platt, A., & Goldstein, D. B. (2018). Drug Development in the era of precision medicine. Nature reviews Drug discovery, 17(3), 183.

Get professional assignment help cheaply

Are you busy and do not have time to handle your assignment? Are you scared that your paper will not make the grade? Do you have responsibilities that may hinder you from turning in your assignment on time? Are you tired and can barely handle your assignment? Are your grades inconsistent?

Whichever your reason may is, it is valid! You can get professional academic help from our service at affordable rates. We have a team of professional academic writers who can handle all your assignments.

Our essay writers are graduates with diplomas, bachelor, masters, Ph.D., and doctorate degrees in various subjects. The minimum requirement to be an essay writer with our essay writing service is to have a college diploma. When assigning your order, we match the paper subject with the area of specialization of the writer.

Why choose our academic writing service?

  • Plagiarism free papers
  • Timely delivery
  • Any deadline
  • Skilled, Experienced Native English Writers
  • Subject-relevant academic writer
  • Adherence to paper instructions
  • Ability to tackle bulk assignments
  • Reasonable prices
  • 24/7 Customer Support
  • Get superb grades consistently




Get Professional Assignment Help Cheaply

Buy Custom Essay

Are you busy and do not have time to handle your assignment? Are you scared that your paper will not make the grade? Do you have responsibilities that may hinder you from turning in your assignment on time? Are you tired and can barely handle your assignment? Are your grades inconsistent?

Whichever your reason is, it is valid! You can get professional academic help from our service at affordable rates. We have a team of professional academic writers who can handle all your assignments.

Why Choose Our Academic Writing Service?

  • Plagiarism free papers
  • Timely delivery
  • Any deadline
  • Skilled, Experienced Native English Writers
  • Subject-relevant academic writer
  • Adherence to paper instructions
  • Ability to tackle bulk assignments
  • Reasonable prices
  • 24/7 Customer Support
  • Get superb grades consistently

Online Academic Help With Different Subjects


Students barely have time to read. We got you! Have your literature essay or book review written without having the hassle of reading the book. You can get your literature paper custom-written for you by our literature specialists.


Do you struggle with finance? No need to torture yourself if finance is not your cup of tea. You can order your finance paper from our academic writing service and get 100% original work from competent finance experts.

Computer science

Computer science is a tough subject. Fortunately, our computer science experts are up to the match. No need to stress and have sleepless nights. Our academic writers will tackle all your computer science assignments and deliver them on time. Let us handle all your python, java, ruby, JavaScript, php , C+ assignments!


While psychology may be an interesting subject, you may lack sufficient time to handle your assignments. Don’t despair; by using our academic writing service, you can be assured of perfect grades. Moreover, your grades will be consistent.


Engineering is quite a demanding subject. Students face a lot of pressure and barely have enough time to do what they love to do. Our academic writing service got you covered! Our engineering specialists follow the paper instructions and ensure timely delivery of the paper.


In the nursing course, you may have difficulties with literature reviews, annotated bibliographies, critical essays, and other assignments. Our nursing assignment writers will offer you professional nursing paper help at low prices.


Truth be told, sociology papers can be quite exhausting. Our academic writing service relieves you of fatigue, pressure, and stress. You can relax and have peace of mind as our academic writers handle your sociology assignment.


We take pride in having some of the best business writers in the industry. Our business writers have a lot of experience in the field. They are reliable, and you can be assured of a high-grade paper. They are able to handle business papers of any subject, length, deadline, and difficulty!


We boast of having some of the most experienced statistics experts in the industry. Our statistics experts have diverse skills, expertise, and knowledge to handle any kind of assignment. They have access to all kinds of software to get your assignment done.


Writing a law essay may prove to be an insurmountable obstacle, especially when you need to know the peculiarities of the legislative framework. Take advantage of our top-notch law specialists and get superb grades and 100% satisfaction.

What discipline/subjects do you deal in?

We have highlighted some of the most popular subjects we handle above. Those are just a tip of the iceberg. We deal in all academic disciplines since our writers are as diverse. They have been drawn from across all disciplines, and orders are assigned to those writers believed to be the best in the field. In a nutshell, there is no task we cannot handle; all you need to do is place your order with us. As long as your instructions are clear, just trust we shall deliver irrespective of the discipline.

Are your writers competent enough to handle my paper?

Our essay writers are graduates with bachelor's, masters, Ph.D., and doctorate degrees in various subjects. The minimum requirement to be an essay writer with our essay writing service is to have a college degree. All our academic writers have a minimum of two years of academic writing. We have a stringent recruitment process to ensure that we get only the most competent essay writers in the industry. We also ensure that the writers are handsomely compensated for their value. The majority of our writers are native English speakers. As such, the fluency of language and grammar is impeccable.

What if I don’t like the paper?

There is a very low likelihood that you won’t like the paper.

Reasons being:

  • When assigning your order, we match the paper’s discipline with the writer’s field/specialization. Since all our writers are graduates, we match the paper’s subject with the field the writer studied. For instance, if it’s a nursing paper, only a nursing graduate and writer will handle it. Furthermore, all our writers have academic writing experience and top-notch research skills.
  • We have a quality assurance that reviews the paper before it gets to you. As such, we ensure that you get a paper that meets the required standard and will most definitely make the grade.

In the event that you don’t like your paper:

  • The writer will revise the paper up to your pleasing. You have unlimited revisions. You simply need to highlight what specifically you don’t like about the paper, and the writer will make the amendments. The paper will be revised until you are satisfied. Revisions are free of charge
  • We will have a different writer write the paper from scratch.
  • Last resort, if the above does not work, we will refund your money.

Will the professor find out I didn’t write the paper myself?

Not at all. All papers are written from scratch. There is no way your tutor or instructor will realize that you did not write the paper yourself. In fact, we recommend using our assignment help services for consistent results.

What if the paper is plagiarized?

We check all papers for plagiarism before we submit them. We use powerful plagiarism checking software such as SafeAssign, LopesWrite, and Turnitin. We also upload the plagiarism report so that you can review it. We understand that plagiarism is academic suicide. We would not take the risk of submitting plagiarized work and jeopardize your academic journey. Furthermore, we do not sell or use prewritten papers, and each paper is written from scratch.

When will I get my paper?

You determine when you get the paper by setting the deadline when placing the order. All papers are delivered within the deadline. We are well aware that we operate in a time-sensitive industry. As such, we have laid out strategies to ensure that the client receives the paper on time and they never miss the deadline. We understand that papers that are submitted late have some points deducted. We do not want you to miss any points due to late submission. We work on beating deadlines by huge margins in order to ensure that you have ample time to review the paper before you submit it.

Will anyone find out that I used your services?

We have a privacy and confidentiality policy that guides our work. We NEVER share any customer information with third parties. Noone will ever know that you used our assignment help services. It’s only between you and us. We are bound by our policies to protect the customer’s identity and information. All your information, such as your names, phone number, email, order information, and so on, are protected. We have robust security systems that ensure that your data is protected. Hacking our systems is close to impossible, and it has never happened.

How our Assignment  Help Service Works

1.      Place an order

You fill all the paper instructions in the order form. Make sure you include all the helpful materials so that our academic writers can deliver the perfect paper. It will also help to eliminate unnecessary revisions.

2.      Pay for the order

Proceed to pay for the paper so that it can be assigned to one of our expert academic writers. The paper subject is matched with the writer’s area of specialization.

3.      Track the progress

You communicate with the writer and know about the progress of the paper. The client can ask the writer for drafts of the paper. The client can upload extra material and include additional instructions from the lecturer. Receive a paper.

4.      Download the paper

The paper is sent to your email and uploaded to your personal account. You also get a plagiarism report attached to your paper.

smile and order essaysmile and order essay PLACE THIS ORDER OR A SIMILAR ORDER WITH US TODAY AND GET A PERFECT SCORE!!!

order custom essay paper